Post Doctoral Fellow in Quantitative Evaluation of Metabolic Pathways at National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD

National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD and surrounding area

POST: Post Doctoral Fellow(Quantitative Evaluation of Metabolic Pathways)

A Postdoctoral position is available in the Laboratory of Metabolic Control (LMC), Division of Intramural Clinical and Biological Research (DICBR), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), Rockville, MD, beginning in August 2012. The Laboratory of Metabolic Control defines the phenotype of disease by determining the kinetic and thermodynamic factors involved in the alterations of metabolic pathways and reactions causing simple genetic and multifactorial complex disease states. From this, it defines therapeutic measures which can return the diseased to the normal phenotype. The Postdoctoral position's work will consist of quantitative evaluation of metabolic pathways under different conditions, with special emphasis on changes in glycolytic and Krebs cycle metabolites, as well as biochemical thermodynamic calculations. The effects of ketosis on neurodegenerative and metabolic disorders will be investigated. Experience with mammalian systems, Western blot analysis, PCR and analysis of signaling pathways are desirable.

REQUIREMENTS:

Candidates must have an M.D. or Ph.D., and less than 5 years postdoctoral experience.

TO APPLY:

For consideration, please email a CV, bibliography, cover letter with a brief description of research experience and interests, and three letters of reference to: Dr. Richard Veech at rveech@mail.nih.gov  .

The NIH is dedicated to building a diverse community in its training and employment programs

FOR DETAILS, PLEASE REFER

https://www.training.nih.gov/postdoc_jobs_nih/view/_31/1211/Quantitative_Evaluation_of_Metabolic_Pathways

PhD Fellowships in Cephalopod population genomics at University of Copenhagen

University of Copenhagen

POSITION: PhD Fellowships in Cephalopod population genomics at the Centre for GeoGenetics

A PhD fellowship is available to commence on 1st March 2012, at the Centre for GeoGenetics, Natural History Museums of Denmark, Faculty of Science, University of Copenhagen.

 PROJECT AREA

Advances in "Next-Generation" DNA sequencing technologies have lead to the development of laboratory and bioinformatic tools that can be used to undertake genomic level analyses with regards to questions related to population genetics and phylogenetics. In this regard, a PhD fellowship is available with the specific aim of applying targetted-high throughput exome sequencing in order to better describe cephalopod populations. Specifically the successful applicant will be required to develop the means to extract high quality DNA from both freshly sampled and archival cephalopod tissues, develop target-capture assays based around the MySelect system, undertake Illumina HiSeq sequencing of the DNA, and analyse the results in both the population genetic and phylogenetic contexts.

 QUALIFICATIONS:

For consideration, the applicants must have the following key skills:

a)      MSc with a strong background in molecular biology, population genetics and phylogenetics

b)      Background knowledge of cephalopod biology

c)      Demonstrated experience with the handling of DNA from degraded and modern samples

d)      Demonstrated experience in working with Second Generation DNA Sequencing platforms and data

e)      Demonstrated ability to independently run research projects, in particular in the field away from day-to-day supervision

f)       Demonstrated internationalisation of previous research such as through peer-review publication.

Skills of additional, although not requisite, interest include:

a)      Teaching and/or supervision experience

b)      Experience in independent fundraising

c)      Outreach experience

 If successfully chosen, the fellowship will be required to start on, or as close to, 1st March 2012.

As the members and collaborators of the Centre are international, the working language of the Centre is English, thus excellent English speaking, reading and writing skills are required.

 PRINCIPAL PLACE OF EMPLOYMENT AND PLACE OF WORK: Centre for Geogenetics, Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen.

 APPLICATION:

The application must contain:

Curriculum vitae (incl. the applicants email address)

List of publications

Motivation for applying (0.5 A4-page)

Transcript of university examinations (in English)

Contact details of 2 persons for references

 For further information please contact Prof. Tom Gilbert (tgilbert@snm.ku.dk )

 Applications will be evaluated by an assessment committee. The applicant will be notified of the composition of the committee. Each applicant will receive the part of the evaluation that concerns her/him. The main criterion for selection will be the research potential of the applicant. In addition experience with some of the above mentioned methods would be an advantage.

 SALARY AND TERMS OF EMPLOYMENT

The successful applicant will be hired as a PhD student at the Faculty of Science, University of Copenhagen for a three year period. Information on the PhD programs at the Faculty of Science can be found at http://www.science.ku.dk/phd/

 Terms of appointment and payment according with the Agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC). The salary depends on seniority, as agreed between the Ministry of Finance and the Danish Confederation of Professional Associations within the range of 23,000-30,000 DKK/month (approximately 3,100-4,000 Euro/month).

 The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.

 The applications should be sent through the electronic job portal of the University of Copenhagen at http://www.ku.dk/stillinger/ .

 Deadline: 22-01-2012

FOR DETAILS, PLEASE REFER http://www.offentlige-stillinger.dk/sites/cfml/kbhuni/kbhuniVis.cfm?plugin=1&englishJobs=Yes&nJobNo=201643&nLangNo=2

High-throughput Genotyping/Sequencing Specialist at CIMMYT

The International Maize and Wheat Improvement Center (CIMMYT)

POST:  High-throughput Genotyping/Sequencing Specialist .

JOB OPPORTUNITIES :The International Maize and Wheat Improvement Center (CIMMYT) is seeking a dynamic and innovative High-throughput Genotyping/Sequencing Specialist with a client-oriented attitude to establish a Genetic-Analysis Service based on genotyping-by-sequencing (GBS) in partnership with Diversity Arrays Technology P/L (DArT). The Service will be located in Mexico and will initially focus on characterizing maize and wheat genetic resources for the Seeds of Discovery (SeeD) initiative coordinated by CIMMYT. SeeD has the ambitious goal of comprehensively characterizing the world’s largest germplasm collections of maize and wheat, which comprise hundreds of thousands of genotypes.   

The primary objectives of this position are:  

·         Establish, lead and manage the operations of a joint CIMMYT/DArT Genetic-Analysis Service in Mexico.

·         Liaise with DArT P/L to implement GBS methodologies, platforms, protocols and pipelines.

·         Supervise a small team of laboratory assistants and technicians performing GBS analyses for clients.

·         Assist colleagues and clients in the interpretation of molecular data.

Your job will entail that you:

·         Optimize and upscale a robust, high-throughput DNA-extraction platform.

·         Adopt, implement and refine GBS protocols.

·         Supervise laboratory operations, design workflows and establish Standard Operating Procedures.

·         Manage the implementation of quality-control/allele-calling pipelines and a Laboratory Information Management System (LIMS).

·         Collaborate with software developers, bioinformaticians and biometricians working on the processing, management and interpretation of data.

·         Collaborate in research design, data analysis, interpretation and publications with SeeD-project participants and other clients.

We are seeking candidates with the following qualifications:

·         A PhD in molecular genetics or an associated discipline.

·         Experience in the characterization of genome representations using high-throughput-genotyping/sequencing platforms.

·         Experience in the practical use of Laboratory Information Management Systems.

·         Understanding and, ideally, experience in the use of genome-wide prediction/selection approaches in breeding programs.

·         Demonstrated ability to deal with logistics challenges related to the processing of large numbers of seeds and DNA samples.

·         Entrepreneurial spirit with strong organizational skills and a client-oriented attitude.

·         Ability to communicate with colleagues and clients in both Spanish and English.

CIMMYT (www.cimmyt.org) is an internationally funded, nonprofit, scientific research, training and development organization dedicated to improving the nutrition, food security and livelihoods of the world’s poor. CIMMYT is a global leader in maize and wheat germplasm preservation, trait discovery, breeding, cropping-systems improvement, and socio-economic analysis for the developing world. The Center has an annual budget of US$100 million and employs approximately 700 staff, including over 100 internationally recruited staff. Besides its headquarters and four research stations in Mexico, CIMMYT has regional centers and offices in twelve other countries in Africa, Asia and Latin America.

The position is based in Mexico. It is for an initial period of 3 years, with the likelihood of periodic renewals subject to performance and availability of funding. We offer an attractive remuneration package comprising a base salary and a range of benefits, commensurate to the candidate’s skills.

CIMMYT is an equal-opportunity employer and strives for staff diversity in gender and nationality.

Apply online no later than December 28th, 2011, go to http://www.cimmyt.org/

Please complete on-line application, including your Cover Letter, competencies and experience for the position and a detailed CV/Resume.

 For further information please contact Peter Wenzl, Head of the Crop Research Informatics Laboratory (CRIL), CIMMYT. p.wenzl@cgiar  or Human Resources Officer, jobs-cimmyt@cgiar.org

FOR DETAILS, PLEASE REFER http://www.cimmyt.org/en/about-us/job-opportunities/1209-201129-high-throughput-genotypingsequencing-specialist-