THE NATIONAL EYE
INSTITUTE, BETHESDA, MD
A
postdoctoral research position is available immediately in the Molecular
Mechanisms Section, Laboratory of Retinal Cell & Molecular Biology,
National Eye Institute (NEI), National Institutes of Health (NIH), to study the
biochemical mechanisms of retinoid metabolism and isomerization in the
retina/retinal pigment epithelium. The Molecular Mechanisms Section conducts
exciting research into retinoid/carotenoid metabolism, and derangements thereof
in blindness, with a long record of achievement in this area. Our focus is on
the vitamin A visual cycle that provides the 11-cis retinal chromophore
essential for vision (For more information please see http://www.nei.nih.gov/intramural/mol_mech_sec.asp
) .
Our
overall goal is a better understanding of vitamin A and its metabolites in
vision and in retinal degenerations, and in developing therapies to treat
derangements of retinoid metabolism. Current projects include structural
studies on the enzymatic mechanism of RPE65/retinol isomerase, analysis of
RPE65 knockin mouse models to understand chromophore requirements for
photoreceptor viability, and the biochemistry of bisretinoid accumulation in
retinal diseases. We have access to a wide range of NEI core facilities,
including biological imaging, genetic engineering, visual function, mass
spectrometry, bioinformatics resources, etc., and to additional expertise at
the NIH Bethesda campus. Training will be provided as required.
Requirements: We are seeking well-trained
applicants with a Ph.D. or M.D./Ph.D., and a strong background in biochemistry
or chemistry, and/or molecular biology, and less than 5 years of postdoctoral
experience in cognate areas of research. The candidate must be highly motivated
and have excellent verbal/written communications and organizational skills.
Prior experience in mass spectrometry methods is a plus.
To Apply: Please send CV and bibliography,
a summary of research accomplishments, description of research interests and
career goals, and the names and addresses of three references to:
Dr. T. Michael Redmond by email at redmond@helix.nih.gov
.FOR DETAILS, PLEASE REFER https://www.training.nih.gov/postdoc_jobs_nih/view/_31/1186/Mechanisms_of_Retinoid_Metabolism_in_the_Retina
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