The
National Eye Institute, Bethesda, MD and surrounding area
POST: PostDoctoral Fellow (Mechanisms
of Retinoid Metabolism in the Retina)
A postdoctoral research position
is available immediately in the Molecular Mechanisms Section, Laboratory of
Retinal Cell & Molecular Biology, National Eye Institute (NEI), National
Institutes of Health (NIH), to study the biochemical mechanisms of retinoid
metabolism and isomerization in the retina/retinal pigment epithelium. The
Molecular Mechanisms Section conducts exciting research into
retinoid/carotenoid metabolism, and derangements thereof in blindness, with a
long record of achievement in this area. Our focus is on the vitamin A visual
cycle that provides the 11-cis retinal chromophore essential for vision (For more
information please see http://www.nei.nih.gov/intramural/mol_mech_sec.asp
) .
Our overall goal is a better
understanding of vitamin A and its metabolites in vision and in retinal
degenerations, and in developing therapies to treat derangements of retinoid
metabolism. Current projects include structural studies on the enzymatic
mechanism of RPE65/retinol isomerase, analysis of RPE65 knockin mouse models to
understand chromophore requirements for photoreceptor viability, and the
biochemistry of bisretinoid accumulation in retinal diseases. We have access to
a wide range of NEI core facilities, including biological imaging, genetic
engineering, visual function, mass spectrometry, bioinformatics resources,
etc., and to additional expertise at the NIH Bethesda campus. Training will be
provided as required.
REQUIREMENTS:
We are seeking well-trained
applicants with a Ph.D. or M.D./Ph.D., and a strong background in biochemistry
or chemistry, and/or molecular biology, and less than 5 years of postdoctoral
experience in cognate areas of research. The candidate must be highly motivated
and have excellent verbal/written communications and organizational skills.
Prior experience in mass spectrometry methods is a plus.
TO APPLY:
Please send CV and bibliography,
a summary of research accomplishments, description of research interests and
career goals, and the names and addresses of three references to: Dr. T.
Michael Redmond by email at redmond@helix.nih.gov .
The NIH is dedicated to building
a diverse community in its training and employment programs.
FOR DETAILS, PLEASE REFER
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