The Trafficking of Acid Proteins and this Pathway's Role in Matrix Disorders
National Institute of Dental and Craniofacial Research, Bethesda, MD and surrounding area
The Matrix Biochemistry Section in the Craniofacial & Skeletal Diseases Branch of the NIDCR is interested in the biochemistry and functions of the family of small integrin-binding proteins called SIBLINGs. This tandem five gene family includes the secreted proteins; osteopontin (OPN, SPP1), dentin matrix protein-1 (DMP1), bone sialoprotein (BSP, IBSP), matrix extracellular phosphoprotein (MEPE), and the most acidic protein in the human body, dentin sialophosphoprotein (DSPP). We and others have shown that mutations in DSPP cause the dominant negative effects of all known cases of the two major nonsyndromic genetic diseases of dentin, dentin dysplasia (DD) and dentinogenesis imperfecta (DGI). Our small research group is currently interested in how these mutations affect the trafficking of this calcium-binding protein and what these insights tell us about the trafficking of many other secreted acidic proteins. The fellow will perform biochemical and cell biology studies using various cell culture models to aid in our understanding of general biological principles of these trafficking pathways as well as explaining specific aspects of these dentin matrix disorders.
REQUIREMENTS:
The successful applicant will have acquired a PhD, DDS, MD (or equivalents) within the last 5 years (IRTA program). They must have a good command of both written and spoken English. Expertise in molecular biological and biochemical procedures as well as experience in basic cell culture are required.
TO APPLY:
Please submit your CV, bibliography, statement of research interests, and the names (with e-mail and telephone numbers) of three references to: Larry W. Fisher, PhD, Matrix Biochemistry Section, CSDB/NIDCR/NIH, Room 228, Building 30, 9000 Rockville Pike, Bethesda, MD, 20892-4320; E-mail: lfisher@mail.nih.gov
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