International Symposium on Innate Immunity: Sensing the Microbes and Damage Signals

Innate Immunity: Sensing the Microbes and Damage Signals (Q7)

Sponsored by Gilead Sciences, Inc. Supported by an educational donation provided by Amgen.
Organizers: Gabriel Nuñez and Akiko Iwasaki
March 4 - 9, 2012 • Keystone Resort  •  Keystone, Colorado

In recent years there have been major advances in our understanding of the mechanisms that are involved in the recognition of microbes and subsequent activation of host immune defenses. Several classes of membrane-bound and cytosolic pattern recognition receptors (PRRs) have been identified and partially characterized. These include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs). Activation of PRRs leads to the production of a large array of pro-inflammatory and anti-microbial molecules that are critical for the elimination of invading pathogens, and activation of adaptive immune responses. A class of cytosolic PRRs is involved in the assembly of the inflammasome, a molecular platform that mediates activation of caspase-1 and secretion of mature IL-1beta and IL-18. Importantly, activation of the inflammasome is also induced by non-microbial mechanisms including endogenous molecules involved in the pathogenesis of metabolic and inflammatory diseases. In addition, there is evidence that autophagy, a cellular process that mediates recycling of intracellular components, is involved in microbial recognition and plays a key role in host defense. The initial sensing of microbes often occurs at mucosal surfaces, but the interplay between recognition of commensal vs. pathogenic microbes on the host immune system is only beginning to be uncovered. The goal of the Keystone Symposia meeting on Innate Immunity: Sensing the Microbes and Damage Signals is to gather scientists working on innate immunity to discuss cutting edge research on the mechanisms that regulate the activation of the immune system by microbes as well as by endogenous damage signals, and to integrate such knowledge in the context of inflammation, homeostasis, host defense, and disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on The Microbiome, which will share a keynote address and three plenary sessions with this meeting.

Abstract Deadlines and Pricing
*All deadlines end at 12:00 midnight US Mountain Standard Time
NOTE: Please use buttons in the blue bar above to Submit an Abstract

• On and before November 3, 2011, the cost is $50.00, which is deducted from your registration fee when you register for this meeting.
• After November 3, 2011, there is an additional $50.00 fee, which is NOT deducted from the registration fee.
  
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• You may submit your abstract on this web site until December 8, 2011.
  (After this date you will need to contact our office about submitting an abstract.)
• Submitting an abstract does not constitute or guarantee registration.

         Detailed Abstract Submission Instructions

Registration Deadlines and Pricing

*All deadlines end at 12:00 midnight US Mountain Standard Time

• You may register for this meeting on this web site until March 4, 2012.
• The Registration Fee includes the Abstract Submission Fee.
• For more information and other registration options, see How to Register.
  
  Non-Student Fees
• The Registration Fee is $715.00 on and before January 5, 2012.
• After January 5, 2012, the Registration Fee is $865.00
  
  Student Fees
• To qualify for the Student Discount, you must be enrolled in an undergraduate, M.S., Ph.D. or M.D. program and complete the Student Verification section.
• The Student Registration Fee is $490.00 on and before January 5, 2012.
• After January 5, 2012, the Registration Fee is $640.00

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What is included in the registration fee?

• Admission to plenary speaker talks and poster displays
• Abstract book
• Breakfast service and coffee breaks
• Refreshments at poster sessions
  
  Registration fee generally does NOT include:
• Lodging
• Transportation
• Lunches (some locations will provide lunch instead of evening social hour food...check program for specifics)
• Dinners

FOR DETAILS, PLEASE REFER http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=1159&subTab=program