Institute for Stem Cell Biology and Regenerative Medicine
Institute for Stem Cell Biology and Regenerative Medicine (inStem), an autonomous Institute established by the Department of Biotechnology, Government of India, at Bangalore, invites applications from suitable candidates for a Research Scientist/Scientific Manager to establish and manage a Stem Cell Engineering Facility (SCEF).
POST: Scientific Manager: Stem Cell Engineering Facility
DESCRIPTION: Under the supervision of Prof. J. Dhawan, inStem and Collaborative Scientific Chair Prof. B.Burgering, University Medical Center Utrecht, Netherlands, the successful candidate will be responsible for managing the newly developed mammalian Stem Cell Engineering Facility (SCEF). Specifically, we are looking for an experienced person to implement state-of-the-art instrumentation and methodology to apply lentiviral expression systems for over-expression and shRNA-mediated knockdown in mouse and human stem cells. The person will be expected to travel between Utrecht and inStem as needed.
RESPONSIBILITIES:
• Management and supervision of all the activities performed in the SCEF and in consultation with Prof Dhawan and Burgering developing a research line on stem cell quiescence or related subject.
• Maintaining a large library of mouse and human shRNA lentiviral constructs.
• Generating and expressing tagged full length expression constructs in lentiviruses for a variety of human and mouse proteins –mostly transcription factors and chromatin modulators.
• Designing and optimizing cellular assays for testing function of overexpression/knockdown in stem cells.
• Implementing standard protocols and procedures to be followed by staff of the SCEF,including biosafety for lentiviral production.
• Assisting in the design and implementation of genome-wide analysis of engineered stem cells.
• Training and assisting researchers to perform over expression and knockdowns in stem cells using lentivirus constructs
QUALIFICATIONS:
• Ph.D. Degree in Cell Biology, Biochemistry, Molecular Biology, Genomics or equivalent.
• Postdoctoral experience preferred, with experience in lentiviral methods.
• Familiarity with mammalian stem cell isolation, culture, functional analysis.
• Familiarity with in vivo analysis of stem cells using FACS, histology
• Applicants can be of any nationality
LANGUAGES:
• English both spoken and written is essential.
START DATE: December 1, 2011 or later.
TENURE: This position is funded by inStem and is initially for three years, extendable to five based on requirements and performance.
APPLICATION PROCEDURE:
An application package consisting of the following information should be sent by email to valsalan@ncbs.res.in with the subject heading “Application for position in SCEF”:
• Up-to-date CV with names and contact details of two referees
• 2-3 page summary of your research career to date and your future goals
Applications will be accepted till the position is filled by a suitable candidate.
FOR DETAILS, PLEASE REFER http://instem.res.in/career/academic-related
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