Post Doctoral Fellow in Mechanisms of Mutagenesis at National Institute of Environmental Health Sciences, Research Triangle Park, NC

National Institute of Environmental Health Sciences, Research Triangle Park, NC

POST: Post Doctoral Fellow(Mechanisms of Mutagenesis)

A postdoctoral position is available in the Laboratory of Molecular Genetics at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. The laboratory investigates the mechanisms by which organisms produce mutations, which are being pursued by genetical and biochemical approaches using the bacterium E. coli as a model system. Specifically, we are aiming to understand the factors that determine the high-fidelity of chromosomal replication by Pol III holoenzyme complex (HE). In this project we are studying: (i) mutator mutants of E. coli whose defect is associated with the polymerase accessory factors, such as newly isolated mutator mutants of the dnaX gene; (ii) The role(s) of accessory DNA polymerases in determining DNA replication fidelity; (iii) the relative contributions of leading and lagging strand DNA replication; and (iv) the role of deoxynucleoside triphosphate (dNTP) pools in mutagenesis. A second main area of research is the mechanism of mutagenesis induced by mutagenic base analogs. Of particular interest is our discovery of a novel detoxification mechanism for N-hydroxylated base analogs, which has been found to be dependent on the molybdenum cofactor.

REQUIREMENTS:

Candidates must have a Ph.D. degree (or equivalent) with less than five years of postdoctoral experience, and have a demonstrated experience in biochemistry, molecular biology or genetics.

TO APPLY:

For consideration, send cover letter, CV including list of publications, and the names/phone numbers/E-mail addresses of three references to:

Dr. Roel M. Schaaper

Laboratory of Molecular Genetics

National Institute of Environmental Health Sciences

MD E3-01, PO Box 12233

Research Triangle Park, NC 27709, USA

E-mail: schaaper@niehs.nih.gov  

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FOR DETAILS, PLEASE REFER

https://www.training.nih.gov/postdoc_jobs_nih/view/_31/1207/Postdoctoral_Position