National
Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD and
surrounding area
POST: Postdoctoral Fellow(Pompe Disease: Search for New
Therapeutic Targets)
The Laboratory of Muscle Stem
Cells and Gene Regulation (LMSCGR) at the NIAMS of the NIH has a position
available for an individual with a background in molecular biology and cell
culture methodology. Within the Lab, our group is focused on translational
research aimed at understanding the molecular and biochemical mechanisms of
skeletal muscle damage in Pompe disease, a rare and fatal muscle disorder
caused by a deficiency of the glycogen-degrading enzyme acid alpha-glucosidase.
The disease belongs to a large group of lysosomal storage diseases. We are
interested in the role of autophagy in the pathogenesis of the disease with the
goal to improve the currently available enzyme replacement therapy. In
addition, we are exploring the effect of a transcription factor (TFEB) on
lysosomal glycogen clearance in newly developed in vitro and in vivo models of
Pompe disease.
The fellow will use previously
generated Pompe mouse models with alterations in autophagic genes, and will be
responsible for the generation of novel transgenic models. Applicants must have an M.D. or a Ph.D degree
with expertise in molecular biology and a previous track record of successful
research. A good command of English is
required.
A wide variety of
state-of-the-art research facilities are available either within the laboratory
or elsewhere on the NIH campus.
To apply, please submit your CV,
bibliography, statement of research interests, and the names of three
references to: Vittorio Sartorelli, M.D., Laboratory of Muscle Stem Cell and
Gene Regulation, NIAMS, NIH; 50 South Drive, Room 1351, Bethesda, MD 20892; E-mail:
sartorev@mail.nih.gov
Cc: Nina Raben, M.D., Ph.D.
E-mail: rabenn@mail.nih.gov
The NIH is dedicated to building
a diverse community in its training and employment programs.
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